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Conserved signals of ncRNA across 73 genes associated with ASD

Small non-coding RNA (ncRNA), like miRNA, siRNA or orphan snoRNAs, could be involved in the pathogenesis of ASD

Erschienen am 15.10.2009
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Bibliografische Daten
ISBN/EAN: 9783838316765
Sprache: Englisch
Umfang: 64 S.
Format (T/L/B): 0.4 x 22 x 15 cm
Einband: kartoniertes Buch

Beschreibung

The Autistic Spectrum Disorders (ASD), are known for their considerable heterogenic clinical presentation. Linkage studies have pointed toward very diverse areas of the genome related to the brain and associated with ASD. We hypothesized that small non-coding RNA (ncRNA), like miRNA, siRNA or orphan snoRNAs, could be involved in the pathogenesis of ASD. A group of 73 genes associated with ASD were selected, proven through linkage studies, presence of biological markers (evidence of SNPs or haplotypes) or candidate genes association studies. A control group of 75 genes, which were predominantly expressed in non-brain tissues was selected. The results showed that the average number of conserved segments per intron in autism specific genes was 3.9, while it was 1.4 in the case of the genes minimally expressed in the brain. A non- parametric statistical test (Mann-Witney) showed a significant difference in degree of conservation between the two groups.

Autorenportrait

I hold an MD from University of Medicine C.Davilla(Bucharest) and a MS in biomedical sciences majoring in Bioinformatics from the University of Toledo(Ohio). I am an Associate Professor and have three ABPN certifications in the field of Psychiatry. I am the Child Psychiatry Residency Training Program Director at the University of Toledo.